Deoxyarbutin, raws li kev sib tw Tyrosinase inhibitor, tuaj yeem tswj cov khoom tsim ntawm melanin, kov yeej cov pigmentation, ploj ntawm cov tawv nqaij dub, thiab muaj cov nyhuv sai thiab ntev ntawm daim tawv nqaij. Cov nyhuv inhibitory ntawm deoxyaarbutin ntawm Tyrosinase yog pom tseeb zoo dua rau lwm cov tshuaj ntxuav hniav dawb, thiab cov nyhuv whitening thiab brightening tuaj yeem ua tiav nrog me me ntawm kev siv. Deoxyarbutin kuj tseem muaj cov teebmeem antioxidant
- Suav lub npe Deoxyarbutin
- Lub npe txawv teb chaws Deoxyarbutin
- Lub npe npe p - (tetrahydro-2H-pyran-2-oxy) phenol
- Cov tshuaj formula C11H14O3
- Molecular hnyav 194.23
- CAS Nr .: 53936-56-4
- English alias 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Purity ≥ 98%
DeoxyarbutinRaws li ib tug tshiab tiam ntawm cosmetic brightening thiab whitening active neeg sawv cev, yog tsuas yog siv nyob rau hauv advanced whitening tshuaj pleev ib ce.
Kuaj
Kev hloov pauv ntawm melanogenesis hauv melanocytes tuaj yeem ua tiav siv cov tshuaj uas sib koom ua ke ntawm cov qauv sib xyaw nrog cov substrate tyrosine thiab yog li kev sib tw ua rau inhibit catalytic muaj nuj nqi ntawm tyrosinase. Peb tau tsim ib qho tshiab tyrosinase inhibitor, deoxyArbutin (dA), raws li qhov chaw no. DeoxyArbutin pom zoo inhibition ntawm nceb tyrosinase hauv vitro nrog Ki uas yog 10-fold qis uas hydroquinone (HQ) thiab 350-fold qis dua arbutin. Hauv cov qauv tsis muaj plaub hau, pigmented guinea npua, dA tau ua kom pom cov tawv nqaij sai thiab ruaj khov uas tau thim rov qab tsis pub dhau 8 lub lis piam tom qab tso tseg cov tshuaj pleev ib ce.
Nyob rau hauv sib piv, HQ induced ib tug luv luv tab sis unsustained daim tawv nqaij lightening nyhuv thaum kojic acid thiab arbutin tsis pom cov tawv nqaij lightening nyhuv. Cov txiaj ntsig tau los ntawm lub vaj huam sib luag ntawm kev ntsuam xyuas kev nyab xeeb tau txhawb nqa tag nrho kev tsim dA raws li qhov ua tau zoo. Hauv kev sim tshuaj tib neeg, kev kho tshuaj pleev xim ntawm dA rau 12 lub lis piam ua rau muaj kev cuam tshuam loj lossis me ntsis txo qis ntawm tag nrho cov tawv nqaij lightness thiab txhim kho lub hnub ci lentigines nyob rau hauv cov pej xeem ntawm lub teeb ntawm daim tawv nqaij los yog cov tawv nqaij tsaus nti, feem. Cov ntaub ntawv no qhia tau hais tias dA muaj peev xwm tyrosinase inhibitory kev ua haujlwm uas tuaj yeem ua rau tawv nqaij lightening thiab yuav siv tau los kho cov kab mob hyperpigmentary.
Taw qhia
Melasma (chloasma) yog ib qho kab mob ntawm daim tawv nqaij pigmentary uas tshwm sim los ntawm lub teeb tsis sib xws rau cov xim dub ntawm lub ntsej muag, uas feem ntau ua rau muaj kev puas siab puas ntsws thiab kev puas siab puas ntsws rau cov tib neeg cuam tshuam. Txawm li cas los xij, cov xwm txheej inciting rau pathogenesis ntawm melasma tsis to taub zoo. Melasma feem ntau tshwm sim rau cov neeg uas muaj Fitzpatrick tawv nqaij hom IV txog VI dua li cov tawv nqaij ncaj (hom I txog III). Melasma kuj tau lees paub tias muaj ntau dua ntawm cov poj niam dua li txiv neej thiab ntau dua ntawm cov neeg Esxias, Latinos thiab African-Asmeskas dua li cov neeg Caucasians. Kwv yees li ntawm 50% mus rau 70% ntawm cov poj niam cev xeeb tub hauv Teb Chaws Asmeskas tsim melasma [3].
Nws tau raug tsim los hais tias cov hyperactive melanocytes nyob rau hauv melasma daim tawv nqaij tsim ntau ntau melanin pigment ntawm tyrosine catabolism txoj kev. Tyrosinase (EC 1.14.18.1), tooj liab-muaj glycoprotein, yog tus nqi txwv enzyme tseem ceeb rau txoj hauv kev no. Melanin synthesis tshwm sim nyob rau hauv tshwj xeeb organelles hu ua melanosomes thiab tom qab ntawd melanized melanosomes raug xa los ntawm melanocytes mus rau cov neeg nyob sib ze keratinocytes, yog li txiav txim siab constitutive thiab facultative daim tawv nqaij xim. Ntau yam ntawm daim tawv nqaij lightening agents yog tsom rau kev tswj melanin synthesis los ntawm kev tawm tsam ntawm tyrosinase kev ua. Tshaj li 50 xyoo dhau los, hydroquinone (1, 4-benzenediol, HQ) tau dav siv los ua tus qauv kub rau prototypical tyrosinase inhibitors hauv kev kho melasma. Txawm li cas los xij, kev saib xyuas tsis ntev los no tau raug them rau qhov muaj peev xwm noj qab haus huv ntawm kev raug mob mus ntev rau HQ, xws li exogenous ochronosis, leukoderma (kev ua haujlwm vitiligo), thiab txawm tias carcinogenesis. kev ua si, muab lub peev xwm ntawm daim tawv nqaij dawb. Meanwhile, cov monophenol tebchaw kuj ua rau nce, los ntawm enzymatic oxidation los ntawm tyrosinase, kom muaj ntau dawb radicals uas ua rau lipid peroxidation thiab ua rau melanosomal membrane puas .In yav dhau los kev tshawb fawb los ntawm peb lub chaw soj nstuam nws tau pom tias deoxyarbutin (4-[(tetrahydro-2H). -pyran-2-yl) oxy] phenol, D-Arb), ib qho glucoside derivative ntawm HQ, muaj kev nyab xeeb dua thiab tsawg dua cytotoxic thaum piv rau nws niam compound hydroquinone. Txoj kev tshawb no tau ua los tshawb xyuas cov tshuaj toxicity thiab kev ua tau zoo ntawm D-Arb ntawm cov qib cellular (qhia ncaj qha ntawm melanosomes) thiab cov tawv nqaij pigmentation siv hauv vivo thiab hauv vitro qauv, ntxiv kev soj ntsuam biosafety ntawm D-Arb nyob rau hauv parallel piv nrog HQ siv rau daim tawv nqaij lightening.
Deoxyarbutin, raws li ib tug tshiab tiam ntawm cosmetic brightening thiab whitening active neeg sawv cev, yog tsuas yog siv nyob rau hauv advanced whitening tshuaj pleev ib ce.
D-Arbutin yog ib qho ntawm cov derivatives ntawm Arbutin, hu ua D-nenenebb arbutin, uas tuaj yeem cuam tshuam qhov kev ua ntawm tyrosinase hauv daim tawv nqaij. Raws li kev tshawb fawb, nws cov nyhuv yog txawm tias 10 npaug ntawm hydroquinone thiab 350 npaug ntawm Arbutin. Hauv kev kuaj tawv nqaij tsiaj, D-Arbutin no tuaj yeem ua kom tawv nqaij sai thiab zoo, thiab tom qab siv tsis tu ncua, cov nyhuv tseem tuaj yeem tswj tau ze li 8 lub lis piam.
Hauv kev tshawb fawb soj ntsuam ntawm tib neeg lub cev, kev siv tshuaj pleev D-Arbutin rau 12 lub lis piam tuaj yeem ua tiav cov teeb meem ntawm daim tawv nqaij tseem ceeb, thiab nws muaj kev txhim kho zoo ntawm cov teeb pom kev zoo txhua hnub thiab cov tawv nqaij tsaus.
Post lub sij hawm: Lub Xya hli ntuj-11-2023
