Nattokinase yog dab tsi?
Nattokinase (NK) yog Bacillus subtilis protein kinase, serine protease tsim los ntawm Bacillus subtilis natto thaum lub sij hawm fermentation ntawm natto. Nws muaj cov haujlwm ntawm kev ua kom cov ntshav txhaws, txo cov ntshav viscosity, txhim kho cov ntshav ncig, softening thiab nce vascular elasticity.
Xyoo 1980, nws tau tshawb pom hauv Natto tias nws muaj 275 amino acids uas tau teem tseg, nrog rau qhov hnyav molecular ntawm 27724. Nws muaj lub luag haujlwm tshwj xeeb ntawm decomposing ntshav txhaws, thiab nws cov nyhuv ua haujlwm yog sawv cev los ntawm chav tsev FU.
Lub cev thiab tshuaj muaj zog
Nattokinase sai denatures thiab deactivates ntawm qhov kub thiab txias tshaj 80 ℃, tab sis rov khov-thaw muaj me ntsis cuam tshuam rau nws.
Nattokinase stabilizes nyob rau hauv 10 feeb thaum pH tus nqi nce ntawm 7 mus rau 12; Thaum tus nqi pH qis dua 5, nws sai sai denatures thiab ua tsis muaj zog.
Tom qab sib tov nattokinase nrog viscous tshuaj, nws muaj peev xwm tswj tau cov kev ua ntawm tsis ntau tshaj 7.5% nyob rau hauv ib tug acidic ib puag ncig nrog ib tug pH nqi ntawm 2-3.
Nattokinase yog ib qho loj molecule ib leeg saw peptidase uas tuaj yeem tawg mus rau hauv cov amino acid fragments lossis me me molecular hnyav peptide chains los ntawm plab hnyuv kua txiv (chymotrypsin, trypsin, cov kua dej hauv cov hnyuv, thiab lwm yam).
Nutritional nqi ntawm natto
Natto yog ib qho khoom noj uas ua tau los ntawm cov taum siav uas muaj fermented nrog cov kab mob. Ntxiv nrog rau kev tswj hwm cov as-ham ntawm cov kua txiv hmab txiv ntoo nyoos, nws kuj tseem muaj qib siab ntawm qee yam khoom xws li cov protein, fiber, calcium, hlau, potassium, thiab cov vitamins ntau dua li taum siav.
Cov ntsiab lus ntawm biotin B1, vitamin B2, thiab lwm yam minerals, tshwj xeeb tshaj yog calcium, hlau, thiab poov tshuaj, txawm tshaj li cov qe. Yog tias sib piv natto nrog cov qe thiab nqaij nyuj, cov ntsiab lus protein ntawm 100g ntawm natto yog sib npaug rau 3 qe lossis 80g nqaij nyuj. Cov amino acid cov ntsiab lus nyob rau hauv natto kuj nplua nuj heev, uas yog vim zus tau tej cov vitamins thiab enzymes thaum lub sij hawm fermentation txheej txheem, xws li amylase, protease, lipase, cellulase, nattokinase, lysozyme, glutamic acid transpeptidase, thiab lwm yam. kev txiav txim ntawm enzymes, protein thiab lwm yam as-ham yog decomposed, yog li ntawd lub digestion tus nqi ntawm natto (85%) yog siab dua li ntawm siav. Soybean (68%), uas yog cov khoom noj muaj txiaj ntsig zoo dua thiab yooj yim dua rau nqus.
Lub luag haujlwm tshawb fawb
NattoKinase (NK) yog cov protein uas muaj lub cev hnyav dua li UK, SK, thiab tPA, muab rho tawm los ntawm cov zaub mov natto lossis fermented los ntawm cov kab mob natto. Nws tuaj yeem nqus tau los ntawm txoj hnyuv. Lub hauv vitro thiab hauv vivo thrombolytic zog ntawm NK tau txiav txim siab los ntawm kev sim, thiab nws tau pom tias hauv vivo thrombolytic kev ua ntawm NK yog plaub npaug ntawm fibrinolytic enzyme. Nws ua haujlwm sai thiab kav ntev ntev hauv vivo, thiab tseem tuaj yeem qhib tPA hauv lub cev, ua rau nws mob me me Nruam txhim kho cov haujlwm fibrinolytic ntawm cov ntshav. Cov neeg mob uas muaj kev pheej hmoo ntawm myocardial infarction yuav tsum tau txhaj 300000 units ntawm urokinase ib zaug, thiab 50 grams ntawm natto muaj 800000 units ntawm urokinase rau thrombolysis.
Lub luag haujlwm tseem ceeb
Cov nyhuv tseem ceeb ntawm nattokinase tshwj xeeb tshaj yog tiv thaiv cov ntshav txhaws. Nattokinase ua tiav cov nyhuv thrombolytic ncaj qha los ntawm hydrolyzing lub ntsiab fibrin ntawm thrombus, thiab tam sim no tsuas yog cov khoom siv ntuj pom los ua kom cov thrombus qub.
Hauv 2015, Tokyo Medical University tau ua qhov kev sim thrombolytic nrog nattokinase hauv tib neeg, lees paub tias nattokinase tuaj yeem txhim kho lub cev muaj peev xwm fibrinolytic thiab ua kom cov ntshav txhaws zoo. Daim ntawv tshaj tawm kev tshawb fawb muaj npe "Single dose oral nattokinase thrombolysis and anticoagulation enhancement" thiab luam tawm nyob rau hauv Scientific Reports 2015; 5: 11601.
Hauv 2016, hauv kev sim 48 teev thrombolysis, 300FU ntawm nattokinase tau siv rau cov laus thrombi tshaj 56 teev, qhia tias thrombus tau yaj tag nrho hauv 2 teev; Qhov ceev ntawm thrombolysis ntawm kev siv 150FU nattokinase yog qhov siab dua li ntawm kev siv tib qhov sib npaug ntawm urokinase [1]. Kev tshawb fawb tau pom tias nattokinase tsis muaj kev cuam tshuam rau plasma fibrinogen, ua rau nws tsis tshua muaj los ntshav. Nws kuj tseem tuaj yeem ua haujlwm zoo rau lub cev tus kheej thrombolytic mechanism, ua rau lub cev tiv thaiv kab mob thrombosis los ntawm kev siv mus ntev, yog li ua kom cov hlab plawv thiab cerebrovascular noj qab haus huv.
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Post lub sij hawm: Sep-11-2023
